The prognostic significance of serum CRP was found in various cancer patients and in the advanced stage of cancers, including renal cell carcinoma [34], [35], [36], [37], [38], [39], [40], bladder [41], [42], [43], [44], breast [45], [46], [47], [48], [49], [50], stomach [51], , colon and rectum [56], , head and neck [62], [63], [64], esophagus [25], [65], [66], [67], [68], [69], prostate [70], [71], [72], [73], [74], lung [75], [76], [77], [78], [79] and pancreatic cancer [80], [81]. This evidence concerns the gene CRP and hereditary clear cell renal cell carcinoma.