In a multivariate Cox proportional regression analysis, with age, LVEF and BNP as continuous and dichotomized variables, both LVEF<50% and BNP were statistically significant independent predictors of CHF (LVEF:<50% HR 4.89; CI 1.49–13.53, p = 0.008 and BNP: HR 4.16, CI 1.63–10.42, p = 0.002). This evidence concerns the gene NPPB and congestive heart failure.