In a study by Pichon et al [7], BNP was correlated to clinical heart failure (as classified by NYHA) in 67 breast cancer patients followed for 62 days (1-984 days) after chemotherapy (anthracyclines with/without trastuzumab) and cut-off level 100 pg/ml was suggested for prediction of CHF. This evidence concerns the gene NPPB and congestive heart failure.