Lee et al [16] studied 86 patients with hematologic malignancies for 2 years and found a correlation between increased BNP concentration and CHF (as diagnosed by Framingham criteria) following antracycline treatment and also Feola et al [6] found that BNP predicted cardiac events (based on reported symptoms or decrease in LVEF>10% at two year follow-up) in 53 breast cancer patients. This evidence concerns the gene NPPB and breast cancer.