For the whole group of multi-examined 73 patients, neither an increase in BNP (n = 36) nor a decrease in LVEF of more than 0.10%-point from the first to the last examination or a final LVEF determination of less than 0.50 (n = 10), predicted CHF (BNP: HR 0.63, CI 0.11–3.78, p = 0.61 and LVEF: HR 0.04 CI 0.0–2561, p = 0.57). This evidence concerns the gene NPPB and congestive heart failure.