During the course of cerebral ischemia and reperfusion, the activation of NF-κB/p65 due to the phosphorylation of its inhibitor I-κBα and phosphorylation of NF-κB/p65 resulted in up-regulated expression of proapoptotic proteins Noxa, Bim and Bax. The gene discussed is BCL2L11; the disease is brain ischemia.