NF-κB is a nuclear transcription factor comprising five different proteins including p50, RelA/p65, c-Rel, RelB and p52, of which RelA/p65 and p50 have been proved to be responsible for the detrimental effect of NF-κB on neuronal injury in cerebral ischemia [7]. The gene discussed is NFKB1; the disease is Cerebral ischemia.