During the course of cerebral ischemia and reperfusion, the activation of NF-κB/p65 due to the phosphorylation of its inhibitor I-κBα and phosphorylation of NF-κB/p65 resulted in up-regulated expression of proapoptotic proteins Noxa, Bim and Bax. This evidence concerns the gene PMAIP1 and Cerebral ischemia.