In this paper, accordingly, we focus on the functional regulation of osteoblast lineage cells in health and osteoporosis, the currently proposed anabolic agents such as teriparatide (PTH(1–34)), sclerostin or DKK1 inhibitors, and strontium that target specific signaling mechanisms underlying the osteoblast function and osteoporosis. Here, DKK1 is linked to osteoporosis.