Although the major known function of the miR-17-92 cluster is related to transcriptional factors c-Myc, E2F, and their autoregulatory loop [66, 67], this cluster also enhances tumor angiogenesis by targeting thrombospondin-1 (TSP1), connective tissue growth factor (CTGF), and a number of proangiogenic targets [109]. Here, CCN2 is linked to neoplasm.