Of them, miR-26a and miR-195, which were found to be significantly downregulated in HCC, might block the G(1)/S transition by repressing retinoblastoma- (Rb-)E2F signaling through targeting multiple molecules, including cyclin D1, cyclin-dependent kinase (CDK)6, and E2F3 [43, 44]. Here, CCND1 is linked to hepatocellular carcinoma.