MiR-216a [79], miR-21 [68], miR-148a [70], miR-221/222 [76], and miR-519d [80] can downregulate PTEN in HCC, leading to the activation of phosphatidylinositide 3-kinases (PI3K)/AKT/mTOR pathway. The gene discussed is AKT1; the disease is hepatocellular carcinoma.