PLAT and age-related macular degeneration: PFD or PFO has also been successfully used as an endotamponade tool combined with a tissue plasminogen activator for the treatment of subfoveal hemorrhages in cases of exudative age-related macular degeneration ARMD by preventing or reducing the risk of massive subretinal hemorrhages as a possible complication of treating exudative ARMD [43, 44].