Work by our lab has shown that a humanized monoclonal anti-CTGF antibody FG-3019 was able to effectively block ECM production in LC and TM cells treated with AH samples from pseudoexfoliation glaucoma (PXFG), primary open angle glaucoma (POAG), and hydrogen peroxide, as shown by a significant reduction in the expression of profibrotic genes [54]. This evidence concerns the gene CCN2 and open-angle glaucoma.