Over the past few years, anti-VEGF agents ranibizumab (Lucentis, Genentech, Inc., South San Francisco, CA), bevacizumab (Avastin, Genentech, Inc., South San Francisco, CA), and more recently aflibercept (Eylea, Regeneron, Tarrytown, NY) have become widely used for the treatment of macular edema from CRVO, resulting in significant visual improvement [13–15]. Here, VEGFA is linked to macular retinal edema.