Among the other 5 OGG1 variants, c.−18G>T and c.977C>G (p.Ser326Cys) have been reported as low-penetrance cancer susceptibility variants [29, 30], while the remaining three were untranslated, synonymous, or intronic variations, meaning that all of them are not highly pathogenic mutations. The gene discussed is OGG1; the disease is cancer.