OGG1 and mutyh-associated polyposis: In accordance with the notion that early-onset cancer is likely to be associated with the germline abnormality of certain gene(s) [16], early-onset colorectal cancer (CRC) is one of the characteristics of MAP [12], and early-onset CRC is thought to occur in patients with biallelic-inactivating mutations of another 8OHG repair gene, OGG1.