MUTYH and mutyh-associated polyposis: Various pathogenic MUTYH mutations, including two major mutations (p.Tyr179Cys and p.Gly396Asp), have been detected in MAP patients in several ethnic populations [12]; however, neither the p.Tyr179Cys nor the p.Gly396Asp mutation has been found in the Japanese population [13–15], and which MUTYH variations are the major pathogenic mutations in the Japanese population remains unclear.