The rat model, in general, recapitulated the reproductive and metabolic features of human PCOS, including the irregular estrous cycles, increased body weight, and ovarian coefficient and the abnormal serum biochemical level of T, A2, E2, LH, LH/FSH, SHBG, TC, LDH-C, HDL-C, and FINS. Here, PLOD1 is linked to polycystic ovary syndrome.