The rat model, in general, recapitulated the reproductive and metabolic features of human PCOS, including the irregular estrous cycles, increased body weight, and ovarian coefficient and the abnormal serum biochemical level of T, A2, E2, LH, LH/FSH, SHBG, TC, LDH-C, HDL-C, and FINS. The gene discussed is LDHC; the disease is polycystic ovary syndrome.