PRNP and prion disease: The review article “Synaptic dysfunction in prion diseases: a trafficking problem?” by A. Senatore et al. http://www.hindawi.com/journals/ijcb/2013/543803/, reviews recent data pointing to intracellular PrP misfolding in synaptic dysfunction and suggests a new model of synaptotoxicity that could explain the phenotypic heterogeneity of prion diseases.