PRNP and amyotrophic lateral sclerosis: In the review article “ER dysfunction and protein folding stress in ALS,” available at the following link: http://www.hindawi.com/journals/ijcb/2013/674751/, S. Matus et al. specifically focus on the role of UPR in amyotrophic lateral sclerosis (ALS), and in the research article “Early delivery of misfolded PrP from ER to lysosomes by autophagy,” available at the following link: http://www.hindawi.com/journals/ijcb/2013/560421/, C. J. Cortes et al. provide experimental evidence of a role of autophagy in the early quality control of misfolded PrP.