The review article “Prion protein misfolding, strains, and neurotoxicity: an update from studies on mammalian prions” by I. Poggiolini et al. available at the following link: http://www.hindawi.com/journals/ijcb/2013/910314/ is a comprehensive review of the prion diseases, looking at the latest information on current knowledge of the mechanisms of PrP conversion and the molecular basis of prion strains. Here, PRNP is linked to prion disease.