CHC with no treatment (PC group) significantly increased serum concentrations of activin-A (P = 0.01 × 10−6), activin-B (P = 0.003), AFRI (0.01 × 10−6), BFRI (P = 0.02), ASFRI (P = 0.0004), and significantly decreased follistatin (P = 0.03 × 10−5) compared to the NC group (Figure 1). The gene discussed is FST; the disease is cryohydrocytosis.