PPARG and fatty liver disease: Studies have reported that PPARγ is expressed at elevated levels in the livers of obese animals, including KKAy mice [9], ob/ob mice [10, 11], db/db mice [11], and 5HT-2cR mutant mice [11], as well as in lipoatrophic A-Zip/F1 mice [12, 13], all of which develop severe hepatic steatosis.