In the present review we will describe the information available on the role of adipokines in RA pathogenesis, focusing on the role of adiponectin, leptin, chemerin, visfatin, resistin, lipocalin 2, SAA3, and a few others, in light of their possible consideration as new potential circulating biomarkers of disease activity and therapeutic response. This evidence concerns the gene RARRES2 and rheumatoid arthritis.