Despite this, high methylation of the ten CpGs in the final 70 bp of the amplicon (i.e., closest to the presumed TSS of CAHM) was clearly seen in CRC but not in normal samples (Fig. 1), indicating that CRC-associated methylation is not unique to Region A but most likely extends across the whole CAHM gene locus. The gene discussed is CAHM; the disease is colorectal carcinoma.