SEPTIN9 and adenoma: While SEPT9 was more frequently methylated in CRC, CAHM was methylated in 8 of 11 adenomas compared with 7 of 11 for SEPT9 (5% threshold for positives), and for 3 of the 11 adenomas the proportion of CAHM that was methylated was at least 2-fold higher than the corresponding value for SEPT9. This was also the case for one Stage I and one Stage II cancer.