Importantly, epidermal growth factor-receptor mediated signalling has recently been reported to modulate intestinal T cell regulation in a murine colitis model,60 and ERRFI1 is also highly expressed in murine LPL T cells, but not splenic T cells.14 We also noted high LPL TEM transcription of another regulator of MAPK signalling, DUSP16; the IBD-associated SNP rs11612508 lies within a DUSP16 intron, but the candidate gene previously reported at this locus is a gene of unknown function, LOH12CR1, based upon eQTL effects reported in adipose tissue.2, 61. The gene discussed is DUSP16; the disease is colitis.