RAD51 and ovarian carcinoma: As shown in Figure 2A-2D, sublethal concentrations of 17-AAG (as determined by 17-AAG dose response curves that were obtained for each ovarian cancer cell line, Supplementary Figure 1) had a significant impact on RAD51 foci after IR causing approximately 70% reduction in foci formation in 36M2 and SKOV3 cells.