Strikingly, in the HR proficient breast cancer cell lines, pathway analysis revealed that exposure to 17-AAG statistically significantly downregulated HR (p<0.005), ATM (p=0.015) signaling and Fanconi Anemia (p<0.005) pathways, which are involved in repair of double strand breaks and interstrand crosslinks (Table 1). This evidence concerns the gene ATM and Fanconi anemia.