Reovirus infection at a MOI of 2 for 72 hours induced significantly higher release of LDH in KRAS mutant HCT116 cells (39.27 ± 2.9%) compared to KRAS WT Hke3 cells (20.64 ± 5.2%; p=0.0057) (Figure 2b), indicating greater disruption of membrane integrity in KRAS mutant HCT116 cells. This evidence concerns the gene KRAS and Reoviridae infectious disease.