In contrast, in the human GCB-DLBCL cell line SUDHL-6 which does not exhibit constitutive NF-κB activity [5] and resting canine PBMCs, p-IKK, p-IκBα and p-p65 were not detected (Fig. 1A). The gene discussed is NFKBIA; the disease is diffuse large B-cell lymphoma.