ABC-DLBCL is characterized by constitutive canonical NF-κB activity that drives lymphomagenesis through up-regulation of NF-κB target genes that promote cellular proliferation (e.g. Cyclin D2) and survival (e.g. XIAP, c-FLIP, and Bcl-2) [4]–[8]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.