Autophagy stimulation is also known to reduce inflammasome mediated IL-1β production [62] and attenuates hyperinflammatory responses from CF cells [29] independent of B. cenocepacia. We demonstrated that IFN-γ was effective in reducing the exaggerated IL-1β production that is observed in response to B. cenocepacia in CF macrophages. The gene discussed is IFNG; the disease is cystic fibrosis.