Interestingly, we found that FoxA3 was also downregulated in the CTNNB1 mutation-positive HCC sample from an HBV-negative patient and in CTNNB1 and SMO mutation-positive HCC, suggesting that the downregulation of this transcription factor is highly associated with mutations in CTNNB1. Here, CTNNB1 is linked to hepatocellular carcinoma.