CTNNB1 and hepatocellular carcinoma: We report that distinct patterns of mutation exist in hepatitis B virus (HBV)-negative and HBV-positive populations, and dramatic differences were found in the expression and function of signaling and metabolic pathways in CTNNB1 mutation-positive HCC samples from the HBV-positive patients (CB+ HCC) compared to para-tumoral tissues at the transcriptomic level.