Moreover, inhibition of Orai1-mediated SOCE by pharmacologic antagonists of the channel or reduction of Orai1 expression by orai1 knockdown impeded the proliferation and migration of ESCC cells in culture, reduced their capacity for invasion, and altered their expression of proteins intimately concerned with migration and invasion (Figs. 5). This evidence concerns the gene ORAI1 and esophageal squamous cell carcinoma.