In the case of squamous cell carcinoma, E-cadherin-mediated cell-cell adhesion was found to induce epidermal growth factor receptor (EGFR) activation, which triggers the ERK/MAPK signaling module and further blocks down-regulation of the anti-apoptotic protein Bcl-2, promoting tumor cell survival [25]. The gene discussed is PROS1; the disease is squamous cell carcinoma.