PROX1 and neoplasm: As shown in Table 2, age (P = 0.002), tumor size (P = 0.013), T-stage (P<0.001), N-stage (P = 0.004), M-stage (P<0.001), nuclear grade (P = 0.003), and PROX1 expression (P = 0.001) were significantly associated with a higher risk of death.