Our previous studies indeed already showed that, although we failed to detect ovine PrP outside the central nervous system, TgOvPrP4 mice could be successfully infected by intra-peritoneal route with a classical scrapie source [21] and showed PrPres accumulation into lymphoid tissues with some prion strains, including classical scrapie and BSE [21], [22]. Here, PRNP is linked to scrapie.