Based on our profound experimental data pointing to an association between tumor-related L1CAM and FoxP3 and pancreatic stromal cells, this study compared immunohistochemically the expression of L1CAM and FoxP3 in pancreatic ductal epithelium (focusing on PanINs as the most frequent precursor lesion) and the stromal composition in CP and PDAC tissues. This evidence concerns the gene L1CAM and neoplasm.