ENO2 and Cerebral ischemia: An increase in NSE has been found in cerebral ischemia and neuronal injury due to a variety of reasons, such as neonatal asphyxia, pediatric febrile seizures, brain infectious diseases, chronic obstructive pulmonary disease, cerebral infarction, cerebral hemorrhage, systemic lupus erythematosus, Wilson's degeneration, and depression.