In SLE, some coding genes had significantly changed antisense transcription in the opposite direction of their sense counterparts, most noticeably IVNS1A BASES (influenza virus NS1A binding protein), RACGAP1 (Rac GTPase activating protein 1) and THBS1 (thrombospondin 1). Here, THBS1 is linked to systemic lupus erythematosus.