IRF2 and systemic lupus erythematosus: In addition, the combined gene set of up- and downregulated DEGs was enriched with potential targets of transcription factors highly relevant to SLE, including AP1 (p = 3.4E-09), E47 (p = 1.1E-8), RFX1 (5.8E-7), IRF1 (p = 1.4E-3), and IRF2 (p = 1.3E-3).