In SLE, some coding genes had significantly changed antisense transcription in the opposite direction of their sense counterparts, most noticeably IVNS1A BASES (influenza virus NS1A binding protein), RACGAP1 (Rac GTPase activating protein 1) and THBS1 (thrombospondin 1). The gene discussed is RACGAP1; the disease is systemic lupus erythematosus.