The cellular characteristics of “sensitive” and “resistant” types of renal cell carcinomas may be controlled by unknown sets of genes that modify expression of GFPT1, UPA1, CDKN1A, GADD45A and ATF3. Global transcriptome analyses using next genaration sequencers will help to resolve these issues. Here, GADD45A is linked to hereditary clear cell renal cell carcinoma.