These studies showed that EGCG exerts its cancer chemopreventive activities by targeting several signaling pathways at different cellular levels, including tyrosine kinase receptors (e.g. EGFR, VEGFR) at the cellular membrane, signaling molecules in cytoplasm (e.g. Akt), and transcription factors (e.g. NF-κB) [29]. The gene discussed is NTRK1; the disease is cancer.