These TAA-based approaches lead to significant tumor responses via complementary cell death mechanisms induced by the direct viral-mediated oncolysis in combination with TAA-specific CD8+ T-cell-mediated killing, causing additional TAAs to be released and presented by DCs to T-cells and resulting in further activation of tumor-specific immune responses, thereby conferring a potent arsenal against systemic metastases. Here, CD8A is linked to neoplasm.