And we found that the high expression levels of phosphor-p38 MAPK (p-p38 MAPK) and p38 MAPK in KCs isolated from 12 weeks high fat diet (HFD)-induced NAFLD rats, which preliminarily revealed the relationship between NAFLD and p38 MAPK pathway [28]. Here, TBCE is linked to metabolic dysfunction-associated steatotic liver disease.