This might explain why the effect of the combination of variants in these two genes on risk of pancreatitis in LPLD was more pronounced than single variants effect in the present study: CTRC-rs545634, located in the 5th intron, could be responsible of an alternate splicing site which would affect this enzyme's integrity and its inhibitory effect, combined to SPINK1-rs11319, located in the 5'UTR, that could affect mRNA stability and be responsible of a lesser production of this trypsin inhibitor, may be compatible with an increased pancreatitis risk. Here, CRISPLD2 is linked to pancreatitis.