The outer membrane lipoprotein (OprI) of Pseudomonas aeruginosa can bind to TLR3/TLR4, and it has been demonstrated to be capable of supporting a strong Th1 response with the production of IFN-γ and TNF-α as well as the induction of IgG2a in a Leishmania major model of infection (51). The gene discussed is IFNG; the disease is infection.