In fact, some authors have found a reduction of polyfunctional CD4 T cells in the peripheral blood of HIV-infected infants, in response to restimulation with BCG, compared with HIV-uninfected infants, or in BAL samples from HIV-infected subjects compared with HIV-uninfected healthy subjects, and finally, an increase in pericardial fluid of TB-HIV patients, with a terminally effector phenotype (143). Here, CD4 is linked to tuberculosis.