The authors did not find any statistically significant difference in the cytokines profile of Mtb-specific CD8+ T cell responses between LTBI subjects and TB patients, while they found that Mtb-specific CD8+ T cells were more polyfunctional (i.e., IFN-γ+TNF- α+IL-2+) in LTBI subjects, according to the role that these cells play in anti-viral immunity (74, 125). This evidence concerns the gene CD8A and tuberculosis.