Our findings suggest that using different strategies of NFκB inhibition may be a valid therapeutic strategy in patients with uncontrolled viremia, such as in patients receiving immunosuppressive therapy; AIDS patients; and at risk patients who have an increased likelihood of developing HHV8 associated diseases including PEL and Multicentric Castleman’s disease, both of which have high levels of lytic viral replication. This evidence concerns the gene NFKB1 and AIDS.