NFKB1 and infection: HHV8 has multiple NFκB binding sites in its genome regulating both latent and lytic genes, and NFκB activity is up regulated during infection (Keller et al., 2000; Lagunoff et al., 2001; Guasparri et al., 2004; Sadagopan et al., 2007; Grossmann and Ganem, 2008).