SLC4A1 and hepatocellular carcinoma: SLC4A2 (AE2) was found to be upregulated in CRC (Song et al., 2012) and hepatocellular carcinoma (HCC) (Wu et al., 2006; Hwang et al., 2009) and similar to SLC4A1 appears to interact with p16 in the cytosol (Song et al., 2012).