As seen in Figure 3, firstly, the mRNA expression levels of most of the SLC4 and SLC26 family members differ widely between normal and cancer tissue, with a clear trend toward upregulation of SLC4A3, SLC4A7, and SLC26A6, and downregulation of SLC4A1 in cancer compared to normal tissue. The gene discussed is SLC4A1; the disease is cancer.