Although SLC26A3 has been shown to be a prognostic marker in colon cancer (Dalerba et al., 2011), a potential causative role of SLC26A3 expression in colon carcinogenesis is still controversial: some investigators have shown that SLC26A3 expression correlates with cell differentiation, i.e., expression of SLC26A3 occurs preferentially in highly differentiated colonic epithelial cells but is low in dedifferentiated cells (Hoglund et al., 1996). This evidence concerns the gene SLC26A3 and malignant colon neoplasm.