As mentioned, the most widely studied of these is SLC4A7 (NBCn1), which has been shown to be upregulated in human breast cancer (Boedtkjer et al., 2013) as well as in cell culture by the ErbB2/HER2 oncogene (Lauritzen et al., 2010, 2012; Gorbatenko et al., 2014), which is upregulated in up to a third of human mammary carcinomas and correlates with poor prognosis, and a SNP in which has been linked to increased risk of breast cancer [see section SLC4A7 (NBCn1), Ahmed et al., 2009; Long et al., 2010; Han et al., 2011; Sueta et al., 2012]. This evidence concerns the gene ERBB2 and breast carcinoma.