Expression of SLC26A2 (DTDST), an exchanger carrying Cl−, oxalate and SO2−4, but not thought to transport HCO−3 (see Alper and Sharma, 2013), was found to be strongly reduced in CRC, likely due to epigenetic silencing (aberrant histone methylation and acetylation) (Yusa et al., 2010). The gene discussed is SLC26A2; the disease is colorectal carcinoma.