SLC9A1 and breast carcinoma: Although the role of Na+/H+ exchange may be less obvious than the role of Na+, HCO−3 cotransport for cellular net acid extrusion and global steady-state pHi control in breast carcinomas (Boedtkjer et al., 2013), cell culture experiments have clearly demonstrated that SLC9A1 plays a prominent and specific role for modulating cell migration, survival, growth and proliferation (Stock and Schwab, 2006; Schwab et al., 2012).