Contributing factors that can explain PD-increased iron accumulation are the elevated expression of the iron import transporter DMT1 (Salazar et al., 2008) and reduced expression of the iron export pore protein Fpn (Song et al., 2010) as well as CP ferroxidase activity (Olivieri et al., 2011; Ayton et al., 2012). The gene discussed is SLC40A1; the disease is Parkinson disease.