Upregulation of IRP1/2 induces a downregulation in Fpn, thus exacerbating iron accumulation in a 6-hydroxydopamine model of PD (Song et al., 2010), but is unable to control Ft mRNA translation despite the elevated labile iron pool in PD (Hirsch, 2006). The gene discussed is SLC40A1; the disease is Parkinson disease.