Other protein ligands like tumor necrosis factor related apoptosis inducing ligand (TRAIL), which binds to death receptors up-regulated in cancer cells to induce apoptosis (Skidan et al., 2009; Lee et al., 2011a; Riehle et al., 2013) and epidermal growth factor (EGF) which targets the EGF receptors over-expressed in many cancers (Zeng et al., 2006; Fonge et al., 2012) are also utilized for modification of polymeric micelles for active targeting. Here, EGF is linked to cancer.