Interestingly, TGFβ1-mediated Erk5 activation did not involve Ras as FTS treatment did not alter Erk5 phosphorylation, thus emphasizing the cell type-specific nature of Erk5 signaling given that Ras involvement is inconsistent between a selection of cancer cell lines (Drew et al., 2012). The gene discussed is MAPK7; the disease is cancer.