PRKN and Parkinson disease: The neuropsychiatric comorbidities in PD have not intensively been studied in an appropriate animal model (Dawson et al., 2010; Campos et al., 2013), although anxiety has been observed in conventional neurotoxin-treated rats and mice and in Parkin-deficient mice (Branchi et al., 2008; Dawson et al., 2010; Rane et al., 2012; Campos et al., 2013).