It has become increasingly apparent that amounts of phosphorylated eIF2α are significantly elevated in sporadic AD brains (Chang et al., 2002; Hoozemans et al., 2005; Kim et al., 2007; O’Connor et al., 2008; Mouton-Liger et al., 2012; Natunen et al., 2013; Segev et al., 2013). Here, EIF2A is linked to Alzheimer disease.