Moreover, in vivo and cell culture experiments reveal that infection with herpes simplex virus type 1 (HSV1: a virus suggested to be implicated in AD development) causes activation of the PKR-eIF2α pathway, resulting in elevations of BACE1 expression and Aβ/C99 generation (Ill-Raga et al., 2011). The gene discussed is APP; the disease is Alzheimer disease.