In accordance with persistently great amounts of phosphorylated eIF2α, expression levels of BACE1, a key enzyme responsible for triggering the production of Aβ peptides, are significantly elevated in AD brains (Fukumoto et al., 2002; Holsinger et al., 2002; Yang et al., 2003; Li et al., 2004; Ohno et al., 2007; Zhao et al., 2007; Cai et al., 2012). Here, BACE1 is linked to Alzheimer disease.