EIF2AK3 and familial Alzheimer disease: We recently found that PERK haploinsufficiency is sufficient to block overactivation of the PERK-dependent eIF2α phosphorylation pathway in 5XFAD transgenic mice (Devi and Ohno, under review), which represent an early onset and aggressive amyloid mouse model based on a combination of five familial AD (FAD) mutations (Oakley et al., 2006; Ohno et al., 2006, 2007).