EIF2A and Alzheimer disease: We have demonstrated that young (3- to 4-month-old) 5XFAD mice, which have not yet showed an increase in eIF2α phosphorylation at baseline levels, exhibit robust activation of the PERK-eIF2α pathway and enhanced Aβ plaque pathology in response to potential environmental risks for AD such as insulin-deficient diabetic conditions and behavioral stress (Devi et al., 2010, 2012).