Moreover, the elevation in eIF2α phosphorylation is successfully recapitulated in different transgenic mouse models of AD that exhibit memory impairments, including 5XFAD (O’Connor et al., 2008; Devi and Ohno, 2010, 2013a,b ), Tg2576 (Kim et al., 2007), and APP/PS1 KI (Page et al., 2006; Mouton-Liger et al., 2012). This evidence concerns the gene APP and Alzheimer disease.