PSEN1 and Alzheimer disease: It has been reported that eIF2α phosphorylation is significantly increased in the brains of sporadic AD patients as well as different lines of amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mice (Chang et al., 2002; Page et al., 2006; Kim et al., 2007; O’Connor et al., 2008; Devi and Ohno, 2010, 2013b; Mouton-Liger et al., 2012).