Furthermore, LPS treatment decreased the total number of outer/mid ML vGlut [F(1, 16) = 172.20; p < 0.001] and PSD95-positive puncta per Dcx cell in both WT and 3xTg-AD mice [F(1, 16) = 41.52; p < 0.001]. The gene discussed is DLG4; the disease is Alzheimer disease.