DCX and Alzheimer disease: We observed a 4.05-fold decrease in the total number of Dcx-positive cells in the GCL/SGZ of 3xTg-AD mice [Figures 4A,B, overall genotype effect: F(1, 16) = 112.65; p < 0.001; post hoc test WT saline vs. 3xTg-AD saline mice: p < 0.001].