Interestingly, the increase in the number of newly-generated microglia/macrophage cells induced by LPS was significantly smaller in 3xTg-AD mice [6-fold and 4.6-fold increase in WT and 3xTg-AD mice, respectively; p < 0.001; genotype and treatment interaction effect: F(1, 15) = 8.102; p < 0.05 Figure 3D], and something similar occurred with reactive-like CD11b/BrdU-positive cells [p < 0.05, genotype and treatment interaction effect: F(1, 15) = 6.51; p < 0.05, Figure 3E]. Here, ITGAM is linked to Alzheimer disease.