Taking all these considerations together, we aimed to determine, for the first time, the potential association between the ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 polymorphisms and subclinical atherosclerosis (assessed by the evaluation of cIMT values and presence/absence of carotid plaques) and CV disease in a large and well-characterized cohort of RA patients. This evidence concerns the gene ABO and rheumatoid arthritis.