HDAC6 has also been implicated as a key player in axonal transport and protein aggregation in several neurodegenerative processes including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) (d'Ydewalle et al., 2012; Simões-Pires et al., 2013). The gene discussed is HDAC6; the disease is early-onset autosomal dominant Alzheimer disease.