TARDBP and frontotemporal dementia: One illustrative example is the overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis: based on clinical, genetic and epidemiological data, these two previously thought of as completely independent entities, seem to be on opposite ends of a spectrum of disease, characterized pathologically by the presence of TDP-43 positive inclusions throughout the central nervous system (14–16).