VWF and platelet-type von Willebrand disease: Quantitative and/or qualitative deficiencies in secreted vWF multimers lead to the most common bleeding disorder in humans, von Willebrand’s disease, which is estimated to affect up to 1% of the population (Sadler, 1998), while elevated serum vWF levels are associated with cardiovascular pathologies (van Galen et al., 2012).