Inhibition of the BMP pathway by reducing BMP‐7 expression leads to mesangial matrix expansion (Miyazaki et al. 2006), while activation of the pathway by reducing gremlin‐1 or overexpressing BMP‐7 expression ameliorates DKD manifestations (Wang et al. 2003, 2006; Sugimoto et al. 2007; Roxburgh et al. 2009; Zhang et al. 2010). The gene discussed is BMP7; the disease is diabetic kidney disease.