The WNT pathway activity, induced by TGF‐β signaling, is also increased in DKD and urinary excretion of MMP‐7 (matrix metalloproteinase 7), a target gene highly upregulated by WNT pathway activation, is shown to correlate with renal WNT pathway activity in animal models of kidney disease (He et al. 2012). The gene discussed is MMP7; the disease is kidney disorder.