In addition to the ApoE-ε2/ε3/ε4 polymorphisms in coding sequence, other common polymorphisms in promoter including −491A/T (numbered relatively to the transcription start site, rs449647), −427T/C (rs769446), and −219G/T (rs405509) were linked with the quantitative expression of ApoE [15, 16] and associated with AD [17–22]. Here, APOE is linked to Alzheimer disease.