Supported by a prevalent study that high IFN signature is associated with endothelial dysfunction, high coronary calcium score and carotid IMT after controlling for traditional cardiovascular risk factors [127], suppression of type 1 IFN in selected patients with heightened IFN signature might therefore be an attractive avenue in preventing cardiovascular disease in patients with SLE. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.