The mRNA expression of RASSF1A, APC and MGMT was found to be decreased in the muscle invasive high grade urothelial cell carcinoma of bladder as compared to the non- muscle invasive low grade group (Figure 2), and this finding was statistically significant (p-value < 0.05) when Wilcoxon signed rank test was applied. This evidence concerns the gene APC and urogenital neoplasm.