As an interesting finding hypermethylation of APC gene promoter was more prominent in invasive high grade urothelial bladder cancer as compared to noninvasive low grade one which is also in line with the previous studies correlating APC methylation with tumor grade, stage and muscle invasion (Berrada et al. 2012; Hoque et al. 2006). Here, APC is linked to bladder transitional cell carcinoma.