Over the past two decades a number of biomarkers such as nuclear matrix protein 22 (NMP22), fibrin degradation product (Fibrin/FDP), bladder tumor antigen (BTA), high molecular weight carcinoembryonic antigen and mucin have been identified and approved by FDA for monitoring and screening of bladder cancers but initial enthusiasm for their clinical utility waned quickly because each of them lacked specificity, reproducibility as well as sensitivity (Ludwig and Weinstein 2005). This evidence concerns the gene NUMA1 and urinary bladder cancer.